Codeine is absorbed from the gastrointestinal tract with greatest plasma concentration developing 60 minutes publish administration. The presence of the large-Unwanted fat, substantial-calorie meal didn't substantially influence the PK of codeine.

Promethazine is definitely an H1 receptor blocking agent. Together with its antihistaminic motion, it offers clinically handy sedative and antiemetic consequences.

Codeine and its salts are well absorbed pursuing both equally oral and parenteral administration. Codeine is about 2/3 as productive orally as parenterally. Codeine is metabolized mainly within the liver by enzymes in the endoplasmic reticulum, the place it undergoes O-demethylation, N-demethylation, and partial conjugation with glucuronic acid.

Keep in mind that this medication has been prescribed because your health care provider has judged the advantage for you is bigger than the potential risk of Unwanted effects. Many people making use of this medication do not need major Negative effects.

Due to the opportunity for promethazine to reverse epinephrine’s vasopressor effect, epinephrine should NOT be utilised to take care of hypotension associated with promethazine overdose.

The concomitant usage of Promethazine with Codeine Oral Option with all cytochrome P450 3A4 inducers or discontinuation of the cytochrome P450 3A4 inhibitor may well bring about lessen codeine levels, greater norcodeine levels, and fewer metabolism by using 2D6 with resultant lessen morphine concentrations. This can be affiliated with a lower in efficacy, and in a few individuals, might result in signals and indications of opioid withdrawal.

No evidence of tumorigenicity was observed in male and female mice at codeine dietary doses as much as 400 mg/kg/working day (close to equivalent to forty five periods the MRHD over a mg/m2 basis).

Carcinogenicity, mutagenicity, and fertility studies haven't been conducted with Promethazine with Codeine Oral Answer; having said that, revealed information and facts is accessible for the person active elements or related active elements.

Bronchial asthma And various Respiratory Conditions: Narcotic analgesics or cough suppressants, which includes codeine, really should not be used in asthmatic patients (see CONTRAINDICATIONS). Nor ought to they be used in acute febrile sickness connected with effective cough or in Long-term respiratory ailment wherever interference with capacity to obvious the tracheobronchial tree of secretions might have a deleterious impact on the affected individual’s respiratory functionality.

Warning For all patients having this drugs: This medication has an opioid drug in it. Opioid medications can place you at risk for addiction, abuse, and misuse. Misuse or abuse of promethazine and codeine can lead to overdose and Dying. When you've got thoughts, communicate with your health care provider. This medication has an opioid drug in it. Serious Unwanted side effects have happened when opioid prescription drugs were being applied with benzodiazepines or other medications that could cause you to drowsy or sluggish your actions. This features sluggish or troubled breathing and Dying. Benzodiazepines incorporate medicines like alprazolam, diazepam, and lorazepam. Benzodiazepines may be made use of to deal with numerous medical problems like stress, difficulty sleeping, or seizures. If you have concerns, talk with your health practitioner. Several drugs interact with promethazine and codeine and might elevate the possibility of side effects like lethal respiratory difficulties. Communicate with your medical professional and pharmacist to make sure it truly is safe to work with promethazine and codeine with all of your medications. Stay clear of alcohol or other medicine and natural products that slow your actions.

Drug interactions may well alter how your prescription drugs function or raise your threat for major Negative effects. This document would not have all possible drug interactions.

Spot the mixture in a container for instance a sealed plastic bag and toss it away within the home trash. You can also abide by your condition or neighborhood recommendations regarding how to safely and securely throw absent PROMETHAZINE WITH CODEINE ORAL Resolution.

You should not use Promethazine VC with Codeine Should you be website allergic to codeine, phenylephrine, or promethazine, or When you've got:

Promethazine is metabolized by the liver to a range of inactive metabolites for example sulfoxides of promethazine, N-demethylpromethazine as well as other glucuronides.